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Saturday, July 30, 2005

 

A possible new kind of vaccination?

The CDC, back in 2001, published a very interesting paper that might change your mind about how and why you get the flu - amongst other things.

Seasonal Variation in Host Susceptibility and Cycles of Certain Infectious Diseases by Scott F. Dowell
is available at
http://www.cdc.gov/ncidod/eid/vol7no3/dowell.htm

It strongly suggests that viruses don't arrive in winter - they were already there, it's just that we get weaker, until a kindling effect can get an epidemic going. He thinks that the photoperiod, and changes in melatonin, are the likely trigger.

He quotes a fascinating observation from 1826, well before jet travel: "...this epidemic affects a whole region in the space of a week, nay, a whole continent as large as North America, together with all the West Indies, in the course of a few weeks, while the inhabitants could not within so short a time have had any communication or intercourse whatever across such a vast extent of country."

But it gets me thinking about an old idea I've kicked around without being able to interest anyone in it.

I wonder if a factor in disease seasonality isn't that the probability of infection vs resistance may depend in part, as well, on the actual number of infectious units initially encountered.

Do we even know whether the gradual exposure to one then 8 then 64 copies of a virus, etc, over days, or weeks might make resistance more likely? That repeated slight exposure might or might not be an effective means of protection generally against infection? (Wouldn't that be nice.)

I mention this because such a mechanism might be expected to logarithmically exaggerate any seasonal effects such as he hypothesizes, mediated by melatonin. Once the snowball got rolling, and exposure came in bunches, it might, to thoroughly mix a metaphor, go like wildfire if the sheer size of the initial exposure is really important. Whereas, during months when everyone's immune system is strong, mild infections of others would expose us only to mild doses of the infectious agent, making the chances of our gaining resistance that much greater as well - if this idea of mine holds at least.

And of course, if repeated or gradually increasing very slight exposures were very likely to produce immunity, this might be quite useful, obviously. We could do that deliberately, as a different sort of vaccination, and one that might be generally applicable as soon as viruses (etc) emerged, without a lot of research and development. Just maybe.

There may well be no such effect of course - but have we ever bothered to find out such a fundamental fact concerning disease transmission? Granted, most in the field would accept that illness-or-resistance is more likely given a large exposure, but the question is, would repeated tiny exposures make developing specific resistance to that disease more likely? Is that part of what's happening during the seasons when viruses or flus aren't virulent?

One interpretation of Dowell's findings might be that he has provided evidence, or at least a hint, that large exposures to infectious agents make resistance more difficult, and less likely.

Even if that's true it doesn't mean that graduated exposure to just any pathogen would be an effective (or wise) countermeasure, but it does get me thinking.

In any case, he's written an impressive and necessary paper, that's very interesting, and might amuse you during flu season.

First published July 30, 2005
Last revised July 30, 2005

Russell Johnston

Saturday, July 23, 2005

 

Poor Man's Air Conditioning

Free air conditioning (or the equivalent) with nothing to buy – a way to beat the worst of the heat waves with little or no expense. Sound good? A year or two ago I figured out how to create a make-shift cooling system for the hottest days of summer that doesn't cost much of anything. The poor man's air conditioning system, you might say.

As it happens I live in a part of the world that's [temperate] in summer, where [air conditioning] in the [summer] is optional. Most people don't bother purchasing it. But there are always periods [in the heat of the summer] when one isn't going to be very comfortable without it.Not to mention that in a heat wave, staying a bit cooler can be life-saving, especially in areas where air conditioning isn't common. For example, University of Delaware climate researcher Laurence Kalkstein has said that a 1992 heat wave in Seattle contributed to around 60 deaths. As I write (July 21, 2005) a headline states that 18 people, mostly homeless, have died of the heat in Phoenix (consider giving a homeless person a frozen water bottle or yogurt container of frozen water on exceptionally hot days.) And the 2003 heat wave in Italy is now credited with causing 8,000 deaths, as well as widespread blackouts due to extra demand by air conditioners. (http://www.reuters.com/newsArticle.jhtml;jsessionid=RGJMFQU50JYCOCRBAEOCFFA?type=worldNews&storyID=8914252)

Certainly the extremes of summer heat isn't to be trifled with: “Severe heat causes more weather-related deaths in the USA than all other weather phenomena combined.” – the Centers for Disease Control (USA Today, May 26, 2005 http://www.usatoday.com/news/nation/2005-05-26-heat_x.htm).

Which is where a simple system of improvised cooling or air conditioning comes in handy, keeping you cool on the hottest summer days, since it's generally the poor who don't have air conditioning in place. If you have a [refrigerator], some empty yogurt containers or something similar, and a solid surface or plate that's metal or stone to put under your feet, then you too have free air conditioning or if you prefer, "temperature regulation" available to you, right now. (Well, it's free if you aren't paying the electricity costs directly and already eat something that comes in plastic tubs.)

The trick is to use the freezer to time-shift the cold, as it were. In the evening, fill up a half-dozen or so of those plastic yogurt container with water - about three-quarters to seven-eighths full, no more, because [water] expands and can split the container. You'll probably find that thin-walled containers work better than sturdier plastic because they're more flexible and more likely to expand than split. It may also help to squeeze the containers as you snap the lids tight on them so that the sides of the containers are pushed in somewhat.

Now in the night, when the [heat] is not so insufferable, your freezer will go to work slightly raising the room [temperature] of your kitchen - but you'll be glad tomorrow.

When the day begins to heat up, go get a frozen yogurt container, by now frozen solid. If you have a concrete floor, as I do, take off your shoes, put the yogurt container between your sock feet, and carry on typing or whatever it is you're doing.

The [ice] will cool the floor, and the floor will cool your feet. True, the air around you will also be a bit cooler, but what will really keep you comfortable are your big feet. They're terrific [heat exchange|heat exchangers], by design - it's part of what they're supposed to do, in [nature] – after all, we didn't evolve wearing shoes.

In an hour or two, switch to the next block of ice, putting the now liquid water in the used container into the fridge or down the drain. Don't put it in the freezer during the day unless you're really lazy. It's best to wait until night to start the freezing part of the cycle again because your freezer is a [heat pump], and the more you make it work during the day, the hotter your place is going to get.

Now, you may not have a concrete floor, of course. You might be cursed with unhygienic carpeting. In which case you need a slate of marble or ceramic tile or stone or metal (aluminum's a great [heat conduction|heat conductor] so you could use a fairly thin piece of aluminum) to put the ice block (still inside its small plastic tub) and your sock feet on.

For more cooling

It's best not to put your feet or ankles against the ice. That's a bit extreme, not quite what bodies are designed for, and you shouldn't find it necessary. On very hot days, I do use a couple of containers at a time, however. It's also very useful to start getting a container or two out and down on the floor at least an hour or two ahead of the time when you'll really start feeling the heat. That way, the concrete floor is already cool when you need it to be - and you may be able to slightly delay the time when the heat is oppressive, as well. Another technique I sometimes use on very hot days is to use a couple of containers at my feet and to shift them back and forth about twenty centimeters from time to time so that I can put my feet down on the concrete where the containers have been sitting for some minutes, for an extra blast of cooling.

For less cooling

For less extreme cooling, wrap a towel around the yogurt container. If you're going through a lot of ice containers, you may wish to cool the surrounding air less. So in order to cool just the floor, not the air generally, wrap a towel around but not under the container.

If you can't find anything like a marble slab to put under your feet, you can wrap the container in a towel and put it beside you - but I don't recommend this as, aside from the bottom of our feet, our bodies aren't built to be extreme heat exchangers. So if you do this, shift the container around a lot so as not to cool one part of your body too much - that sort of differential cooling just ain't that natural. Better: just go find a slab of something.

For only a little bit of trouble, you can enjoy a significantly cooler body and a maybe even a slightly cooler [environment] during the hottest parts of the day. You might even want to use this instead of your present air conditioning on some days, if you only need to cool yourself and not the whole house and you want to be a little more [green party|green].

As a bit of an aside, I must admit it would be nice to have a nifty solution to the problem of the yogurt containers cracking sometimes from ice expansion. Using thinner containers helps a lot, but I keep thinking that something like a stick of styrofoam long enough to go to the bottom of the container slipped into the center of the container while the water's liquid, or even better, a sealed plastic tube filled with air that's not quite as tall as the container, might absorb most of the expansion by allowing itself to be crushed slightly in the center. The only thing common and cheap that would do the trick that I can think of would be strips of bubble-wrapping rolled up and tied with string or wire to make a cylinder a bit longer than the tub is high, or a column of styrofoam if you have some of that packing material handy.

Some other tips commonly given for hot times: eat small meals more frequently, since digestion is a large task that creates considerable heat itself, stay hydrated and keep your electrolyte levels up with some form of salt.

The first signs of heat exhaustion are being very thirsty and a dry mouth. Less urination may mean the body is growing short of liquid. Dizziness and fatigue and also signs. Hot and dry skin is a red flag – heat stroke is setting in and death may follow.

For more information, see the CDC site: http://www.bt.cdc.gov/disasters/extremeheat/index.asp

Russell Johnston, completeconfusion.com

first posted on the net June 6 2004

last revised July30, 2005


Thursday, July 14, 2005

 

Steroids and Moneyball

Steroids and Moneyball

N.B.! THE FOLLOWING ARTICLE IS SPECULATION AND NO LEGAL CLAIM OF CRIMINAL ACTIVITY BY MANAGEMENT OF ANY LEAGUE , TEAM, OR SPORT IS MADE IN THIS ARTICLE. NO DEFINITE CLAIM AS TO THE STATE OF MIND, KNOWLEDGE, OR INTENTIONS OF ANY PRESENT OR PAST MEMBER OF MANAGEMENT OF ANY LEAGUE OR TEAM WITHIN OR WITHOUT THE MLB IS MADE HEREIN.

I'm beginning to think that while there's something to "moneyball", it's not the real story. Sure, stats help you select players and always have, but all the hype may (also) have largely have been a useful cover story for the real bargain hunting: namely consciously going out and finding young players with merely good stats who weren't taking steroids, but were likely to do so, or who had just begun to - who therefore were going to be a whole lot better than their stats would make you think.

Seems to me, speculating, that Billy Beane was in an excellent position to watch that economic process take place, understand it exactly, and exploit it thoroughly. It would be hard to argue that he has uniformly avoided hiring or retaining all players who might use steroids.

So what did Billy Beane know and when did he know it? He's said what he lacked as a player was (paraphrasing badly, from memory) "that he had real skills that excited the scouts but lacked the will to do whatever it took to be a really good baseball player." We now know (as he presumably knew way back when - unless my timeline is way off, and maybe it is) exactly what "whatever it took" cashes out to - performance enhancing drugs that were known to carry real risks by then. Certainly, unlike a certain Californian governor, Beane wasn't willing to do whatever it took to his body pharmaceutically to have a truly spectacular career at any price - that much seems clear in any case - but in struggling with this question, or once he was in management, Beane may have realized that he had some very valuable economic information about just which undervalued players were in fact likely to become stars. With regard to that timeline, Billy Beane's debut in the majors was in 1984 and his last game in 1989.

Perhaps his consolation prize for knowingly watching less highly talented cheaters pass him by and get the biggest headlines and longest careers as players, was to proceed directly to management and cash in this knowledge. ("Assuming any major league player has ever used steroids during this, earlier or subsequent periods.") As the old saying goes, the fox knows many things, but the porcupine knows one big thing. Steroids, and just whose stats were about to climb skyward thanks to them, were a big thing to know about back then "if anyone in baseball has used steroids to enhance their performance." Very big, if you were building a ball club on a relatively small (but still multi-million dollar) budget.

The key realization in this, would be that players who hadn't taken steroids but were now started, or were about to, were the greatest bargains in the marketplace, with the greatest hidden upside possible, unreflected in their known stats. Maybe Billy Beane was the first person to both figure that out, if he ever did, and then to discern the extreme economic value that seemingly small bit of knowledge represented. Maybe he still hasn't, or hasn't consciously figured this out to this day. But if I were a betting man....

That doesn't mean that there's nothing to sabremetrics. Not at all. But on base percentage (under whatever terminology) isn't a new concern, and the new stats and studies may actually have been very much the smaller part of the moneyball story. Or, the renewed value of novel statistical studies may have come about precisely because steroid use had altered so many trends and made traditional expectations, once better founded statistically, had become somewhat obsolete. (See initial legal claim.)

Maybe congress should have called one more witness. But then again, pardon my cynicism, but perhaps that's precisely why they didn't call on a bunch of prominent management figures to testify.

A REPLY TO UNPUBLISHED OBJECTIONS/QUESTIONS FROM DAN AGONISTES (to a previous version of the above specualtion) (danagonistes.com):

With it's concentration on OBP, pitching accuracy, and so much more, I agree that there's much to moneyball - but I do wonder whether it's a full and adequate explanation of Billy Beane's success. However we have to keep in mind that what was privately known by some or many experts but kept private as a business advantage can't be directly known. We don't know this sort of thing except by, say, looking at prices paid for various types of pitchers to see what knowledge has been discounted, or not, as in any other market. No doubt much proprietary knowledge about baseball development was neither very uncommon nor widely broadcast. I do begin to suspect that a flurry of publicity over moneyball may in part at least have been a good cover for the real bargain hunting, which was looking for players whose performances were just about to get pumped up. Also, as I'll argue shortly, statistical study of baseball skills development can hardly help but incorporate knowledge of what are in fact the consequences of steroid use "if indeed statistically significant numbers of developing baseball players have ever taken steroids" - last clause applies to whole paragraph.

I don't think Billy Beane or anybody else had to push steroids - the carrot of multi-million dollar contracts and fame was surely more than sufficient for many players “if indeed any have taken steroids”, and these humongous incentives were already in place. Not to mention that the legal implications from civil suits spurred by later medical problems by anyone pressured to take steroids could obviously have been massive, too. Plus, and this is very important to note, I'm not saying he or anyone else in management isn't ethical (as ethical as other non-whistle blowers at least, and there are hordes of those) much less a criminal, or performed any act that would now be criminal. I'm only saying that he or they may have realized just how important that key data point, steroid use, was in changing all the other data points; and figured out that this meant that the real, spectacular bargains in the marketplace were those players whose known stats reflected no steroid use and who were middle-of-the-pack or a bit better - but who had recently started to take steroids seriously, or whose known attitude or associates suggested they would or might soon "assuming any steroid use at all" - quoted fragment applies to paragraph as a whole.

In fact, to exploit this for economic advantage, it might only have been necessary to invest broadly in players from places where steroid use was known to be relatively low, such as colleges without a high priority on athletics in general or baseball in particular. The purpose of such a strategy being to scoop up players who hadn't yet been exposed to a lot of steroid use, or seriously considered it. Conversely, a related strategy would have been, or might still be, to investigate carefully and avoid all players who were longer-term steroid users since their stats and market price had already "discounted" that steroid use, giving them a much lower upside under modern conditions (as well as a possible health and injury downside.) That is, there would be no further large "bounce" from steroid use available to such long term users. Thus, paradoxically, one could economically exploit the trend toward steroid use efficiently by actively avoiding some steroid users – namely the long term users - or even all steroid users, in effect counting on the fact that at least some of there still pure players might start using on their own. Economic profit lies in the upside, after all.(Literally so, since "economic profit" is a technical term within the field of economics to designate above-market profits, and that's how I'm using it here). To summarize this "steroid avoidance" strategy, players who have been taking steroids for some while and don't have a further upside possibility from now deciding to live "better" through chemistry are, relatively speaking, worse investments in the long term.

Of course, sabremetrics, etc could have discovered and exploited such trends, partially at the very least, with or without having explicitly discovered the underlying variable of drug use - but too many people in the industry knew precisely what was going on for that to be an entirely credible claim, I suspect. And who better to explicitly notice the economic and career consequences of drug use than a talented player who was deprived of the shining career it looked like he was going to have, in no small part because of widespread steroid abuse by so many others who didn't care as much about their future health? That's a description that may well fit Billy Beane, a first round draft pick in 1980, to a T. One has to imagine that watching that happen to one's career hopes would have stung deeply, "if indeed anyone in baseball Billy Beane knew or knew of ever took steroids during this period." Billy's a very bright guy by all accounts, I suspect he knew just what had happened to his career "whatever that was", and I also suspect his being bone lazy or ill-omened despite his talents wasn't the backstory to his unspectacular career. Maybe I'm wrong - it's very difficult to vouchsafe what other people thought or knew and kept largely to themselves, but I do believe a good argument can be made that he was in a position to know these things and that if he did, the consequences over the last decade or so would have been similar to what we've seen. See beginning legal claim.

Whatever anyone knew, it's no doubt true that a certain amount, maybe even a very large amount, of the hidden upside that moneyball-type statistical investigations have uncovered and exploited has in fact been made up of diverse markers of steroid use (such as, say, paradoxical increases in stats when players move up to a higher class of league), together with novel trend changes caused by steroid use "if steroids have been in use." Whether or not anyone ever discerned that as an underlying cause wouldn't have prevented the economic exploitation of such secondary trends once they were unearthed. An obvious possible example of a novel change in trends - is increased injury. This could perhaps be a factor explaining why it's now true that early pitching talent is heavily discounted because injury is pretty likely to erase that early promise, or injury-related changes in trends might only affect hitters to a large degree "if steroids have ever been used."

In horseracing, drug use leads to a sharply increased risk of injury (harness racing being one historic response to that risk, one may speculate, but see the initial legal claim again.) This risk comes about not so much because of direct damage to the body as indirect injury, since performances are pushed over the redline with erratic consequences. Nature likes to work within what structural engineers would call "margins" and drugs work in good part simply by overriding these safety margins, enforced by fatigue and otherwise. If you push your fighter aircraft over the redlines on the dashboard dials and outside its secure "performance envelope" more mechanical breakdowns occur, not just to moving components of the engine, but also to passive restraint mechanisms that are the avionic equivalent of hamstrings. The same sort of injuries have likely been happening in baseball "if indeed steroids have been used in major league baseball at any time." I think it would be difficult indeed to argue that today's players are markedly more robust, and less susceptible to injury than previous generations. (Lawyers are a leading cause of double negatives.) It would be somewhat confounding to medical science if steroids have nothing at all to do with recent injury trends "if indeed steroids have ever been used by major league baseball players." (Lawyers are a contributing cause of quotation mark usage.)

A large economic/investment change from widespread steroid use in earlier career stages "if any players have taken steroids early in their career or otherwise" would be a trend toward more drop outs from injury of talented players who don't reach the majors at all, shorter careers for first draft picks than in earlier times, and a consequent advantage for those teams making broader investments in many cheaper players rather than making very heavy investments in a very few highly performing young players who are now more likely not to have a career at all (or to be passed by egregious drug abusers.) A strategy of broader investment sounds somehow familiar, to me, and might to the reader. (Quoted fragment applies to the paragraph as a whole and by implication, to each sentence of same.)

Also published at everything2.com with the following addendum:

In case this article disappears from everything2.com, I might mention, with the greatest respect to Everything2, that I will be posting articles of mine censored from everything2 (about twenty percent of the articles I've written for them so far) at my blog at completeconfusion.com. Revisions and fuller versions of articles and late additions to bibliography will also be posted there for similar reasons - censorship always has a degree of predictability, so I do self-censor some of what appears under my rubric at everything2 in advance of publication there; needless to say. I don't mention this self-censorship as a slight to everything2 in any way at all, since this is of course an all but inevitable consequence of any external restraint on speech.

I'm very grateful to Everthing2. Everything2 is a private concern with every legal right to censor what appears there, for any reason whatsoever, which I recognize and respect fully. I'm grateful for the opportunity to publish many things at everything2.com, as well as being glad that the internet is large.

Initial message similar to first part sent July 12, 2005. First published here and on the web July 14, 2005. Last revised July 14, 2005.

Russell Johnston

This article may be found at:
http://confusioncomplete.blogspot.com/2005/07/steroids-and-moneyball.html
Note that this address is confusioncomplete, etc not completeconfusion, etc. Suitably confusing, eh?
completeconfusion.com however does redirect to the above site at blogspot.


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